Dr. AGBONIFO-CHIJIOKWU, EJIME (LECTURER II)

Email: eagbonifo-chijiokwu@delsu.edu.ng

• Area of Specialization: Endocrine and Metabolic Physiology
• Department of Physiology
My Publications
• Oyovwi MO, Chijiokwu EA, Ben-Azu B, Atere AD, Joseph UG, Ogbutor UG, Udi OA (2025) Potential Roles of Natural Antioxidants in Modulating Neurodegenerative Disease Pathways. , Mol Neurobiol. /Springer Nature
  doi: 10.1007/s12035-025-04874-w. Vol. Pages:
  
  
• 1 Chinedu Charles Onyekweli, Benneth Ben Azu, Kingsley E. Nwangwa, Mega O. Oyovwi, Julian E. Nwangwa, Ejime Agbonifo Chijiokwu, Simon I. Ovuakporaye, Oghenetega B. Onome, Shalom U. Nwabuoku, Rume A. Rotu, Joseph G. Uchechukwu (2025) Autophagy-dependent pathways mediate memory and testicular impairments induced by a high-fat diet in rats, which can be reversed by epigallocatechin-3-gallate, Nutrire /Springer
  https://doi.org/10.1186/s41110-025-00338-2 Vol.50, 35 Pages:
  
  
• 2 Oyovwi MO, Chijiokwu EA, Rotu AR, Jeroh E, Chinwuba P, Ben-Azu B, Osirim E, Nwangwa EK. (2025) Quercetin prevents single prolonged stress-induced posttraumatic stress disorder and neurochemical changes via antioxidant, anti-inflammatory and antiapoptotic mechanisms in rats. , Neuroscience/Springer
  doi: 10.1016/j.neuroscience.2025.04.036. Epub 2025 Apr 26. PMID: 40294843. Vol.7;576 Pages: 199-212
  
  
• 4 Ekhoye E, Agbonifo-Chijiokwu E, Nwangwa E. (2024) Omega-3 PUFAs counteracts high fructose diet-induced gonadal impairment via fortified antioxidant defense. , Physiol Pharmacol
  http://ppj.phypha.ir/article-1-1980-en.html Vol.28 (3) Pages:
  
  
• Onyekweli CC, Ben-Azu B, Oyovwi OM, Nwangwa EK, Ovuakporaye IS, Moke GE, Agbonifo-Chijiokwu E, Onome BO, Emojevwe V, Rotu AR. (2024) Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced autophagy, hormonal dysregulation, testicular and brain oxidative stress, and neurochemical changes in rats. , Food Chem Toxicol
  doi: 10.1016/j.fct.2023.114340. Vol.184 114340 Pages:
  
  
• Lynda EO, Kingsley NE, Obukohwo OM, Benneth BA, Victor E, Simon OI, Agbonifo-Chijiokwu E, Oghenetega OB. (2024) Arjunolic acid reverses fluoxetine-induced alterations in testicular steroidogenic enzymes and membrane bound ionic pump imbalance through suppression of oxido-inflammatory stress and apoptosis., JBRA Assist Reprod.
  doi: 10.5935/1518-0557.20230062. Vol.26;28(1) Pages: 66-77
  
  
• Oyovwi Mega Obukohwo, Tesi Prince Edesiri, Ben-Azu Benneth, Emojevwe Victor, Ojetola Abodunrin Adebayo, Joseph G. Uchechukwu, Onome Bright Oghenetega, Rotu Arientare Rume, Ovuakporaye Irikefe Simon, Ejime Agbonifo-Chijokwu, Nwangwa Eze Kingsley, Falajiki Yewande Faith, and Okwute Patrick Godwin. (2023) -Ribose-L-Cysteine Attenuated Polychlorinated Biphenyls Mediated Neuroendocrine-Transmembrane Ionic Pump ATPase Disruption and Peroxinitrite Formation in a Rat Model: A Possible Role of Testicular Antioxidant and Androgenic Enzymes. , Trends in Science
  https://doi.org/10.48048/tis.2023.5879 Vol.20(10) Pages: 5879
  
  
• Chijiokwu, E.A., Nwangwa,.E.K., Oyovwi, M.O., Ben-Azu,B., Naiho, A.O., Moke, E.G., Emojevwe, V., Ehiwarior, P.A., Nwabuoku, U.S., (2023) Possible homeostatic, glucose uptake mechanisms and hepato-pancreatic histological effects of intermittent fasting exercise, starvation, and honey in streptozotocin-induced diabetes in rats. , Nutrire /Springer
  https://doi.org/10.1186/s41110-023-00204-z Vol.48(16). Pages:
  
  
• Agbonifo-Chijiokwu, E., Nwangwa, K.E., Oyovwi, M.O., Ben-Azu,B., Naiho, A.O., Emojevwe, V., Ohwin, E.P., Ehiwarior, A.P., Ojugbeli, E.T., Nwabuoku, S.U., Moke, E.G., Oghenetega, B.O., (2023) Underlying biochemical effects of intermittent fasting, exercise and honey on streptozotocin-induced liver damage in rats. , Journal of Diabetes Metabolic Disorder/ Springer
  DOI: 10.1007/s40200-022-01173-2 Vol.4;22(1) Pages: 515-527
  
  
• Mega O Oyovwi, Ovuakporaye I Simon, Tesi P Edesiri, Ben-Azu Benneth, Emojevwe Victor, Nwangwa E Kingsley, Rotu A Rume, Falajiki Y Faith, Onome B Oghenetega, Ejime Agbonifo Chijiokwu (2022) D-ribose-L-cysteine Activated Autophagic Related Protein Pathway: A Possible Therapeutic Mechanism for Attenuating Testicular Maladaptive Responses., Biochemistry and Analytical Biochemistry,
  DOI: 10.35248/2161-1009.22.11.441 Vol.11:441 Pages:
  
  
• Ogbutor UG, Nwangwa EK, Nwogueze BC, Igweh JC, Ugoeze FC, Ezunu E, Chijiokwu EA (2022) Proinflammatory and Anti-inflammatory Cytokine Response to Isometric Handgrip Exercise and the Effects of Duration and Intensity of the Isometric Efforts in Prehypertensive Participants. , J Chiropr Med.
  DOI: 10.1016/j.jcm.2022.05.002 Vol.21(3) Pages: 177-186
  
  
• Agbonifo-Chijiokwu, E., Nwogueze, B.C., Ehiwarior, P.A., Ohwin, P.E., Aisuodionoe, E.M., Daubry, T.M.E., Oghenerukevwe, O., Nwabuoku, U.S., Oluwe, G., Ebuwa, I.E. (2022) Sperm quality and testicular histological changes in Wistar rats treated with cannabis sativa ethanolic extract., Neuroquantology
  DOI:10.14704/NQ.2022.20.15.NQ88525 Vol.20 (15) Pages: 5228-5235
  
  
• M.O. Oyovwi, B. Ben-Azu, E. Agbonifo-Chijiokwu, E.G. Moke, A.M. Ajayi, J.I. Wilson, P. Omenogor, E.K. Nwangwa, J.C. Igweh (2022) Possible mechanisms involved in the prevention and reversal of chlorpromazine-induced testicular damage by taurine and coenzyme-Q10 in rats., Nutrire /Springer
  doi: 10.1016/j.reprotox.2021.01.013 Vol.47 (2) Pages: 1-15
  
  
• Chijiokwu, E.A., Nwangwa, E.K., Oyovwi, M. O., Naiho, A. O., Emojevwe, V., Ohwin, E. P., Ehiwarior, P. A., Ojugbeli, E. T., Nwabuoku,U. S., Oghenetega, O. B., Ogheneyoma, O. O. (2022) Intermittent fasting and exercise therapy abates STZ-induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic and glycolytic pathway, Physiological Reports
  doi: 10.14814/phy2.15279. Vol.10, e15279. Pages:
  
  
• Mega, O.O., Benneth, B.-A., Edesiri, T.P., Rume, R.A., Victor, E., Rotu, R.A., Oghenetega, B.O., Agbonifo-Chijiokwu, E., Kingsley, N.E., Andrew, U.O., Adebayo, O.G (2022) Possible mechanism involved in the testicular-protective property of quercetin in rats exposed to endosulfan toxicity, Pesticide Biochemistry Physiology
  doi: 10.1016/j.pestbp.2022.105224. Vol.188, 105224 Pages:
  
  
• Mega,O.O., Edesiri, T.P., Victor, E., Kingsley, N.E., Rume, R.A., Faith, F.Y., Simon, O.I., Oghenetega, B.O., Agbonifo-Chijiokwu, E (2022) D-ribose-l-cysteine abrogates testicular maladaptive responses induced by polychlorinated bisphenol intoxication in rats via activation of the mTOR signaling pathway mediating inhibition of apoptosis, inflammation, and oxidonitrergic flux. , Journal of Biochemical and Molecular Toxicology.
  doi: 10.1002/jbt.23161. Epub 2022 Jul 13. PMID: 35822628. Vol.36 (10) Pages: e23161.
  
  
• B Enebeli, EK Nwangwa, BC Nwogueze, A Nzenegu, E Agbonifo-Chijiokwu, O Omeru and EI Ebuwa (2021) In Vivo Attenuation of Alcohol- and Cadmium Chloride–Induced Testicular Toxicity Modulated by Silymarin in Male Wistar Rat. , Biol Trace Elem Res/Springer
  doi: 10.1007/s12011-021-02944-3. Epub 2021 Nov 10. PMID: 34761358. Vol.200 Pages: 3666–3676.
  
  
• Nwogueze BC, Ojieh AE, Wilson JI, Ovuakporaye SI, Ohwin PE, Aisuodionoe EM, Daubry TME, Agbonifo-Chijiokwu E, Eke CN, Omeru O, Ebuwa EI, Aloamaka CP (2021) Down regulatory response of reproductive potentials in stress-induced rats supplemented with clomifene citrate: The fate of infertility. , Biomed Pharmacother. 143:112208.
  doi: 10.1016/j.biopha.2021.112208. Vol.143:112208. Pages:
  
  
• Godsday, O.U, Kingsley,N.E, Chukwuebuka,N.B, Ephraim,C., Emmanuel,E., Ejime,A.-C, Chukwuka,I.J. (2021) Isometric Handgrip Exercise Training Improves Spirometric Parameters and Pulmonary Capacity. , Pathophysiology
  doi: 10.3390/pathophysiology28030022. PMID: 35366278; PMCID: PMC8830447. Vol.28 Pages: 328-338
  
  
• Chukwuebuka N.B, Elias D.T.M, Ijego A.E, Peggy O.E, Ejime A.C, Omeru O, Yabrade T.P, Nwanneamaka E.C, Ikemefuna E.E. (2021) Changes in Antioxidant Enzymes Activities and Lipid Peroxidase Level in Tissues of Stress-Induced Rats. , Biomed Pharmacol J.
  DOI: https://dx.doi.org/10.13005/bpj/2161 Vol.14(2) Pages: 583-596
  
  
• Ijego A.E, Chukwuebuka N.B, Okechukwu S.A, Ori E.C, Elias D.T.M, Yabrade T.P, Ejime A, Tarela O.E, Ikemefune E.E. (2021) Assessment of Progressive Resistance Exercise Training on CD4 Count and Weight of People with HIV/AIDS in A University Teaching Hospital, Ebonyi State Nigeria., Biosc.Biotech.Res.Comm.
  DOI: http://dx.doi.org/10.21786/bbrc/14.2.32 Vol.14(2) Pages: 654-660.
  
  
• Ohwin, P.E, Ofulue, O.O, Nwagueze, B.C, Agbonifo-Chijiokwu, E, Omeru,O., Nwangwa E.K. (2021) Quantitative Assessment of Age and Gender Related Changes in Human Lacrimal Fluid Composition in Subjects. , Journal of Pharmaceutical Research International, 33(34B):89-99
  DOI: 10.9734/jpri/2021/v33i34B31851 Vol.33(34B) Pages: 89-99
  
  
• Agbonifo-Chijiokwu E, Nwangwa E.K, Obataze A, Moke G.E, Aidamoisa F. (2020) Abdominal Obesity and Its Association with Socioeconomic Indicators Among Multiparous Women. , Int. J of Forensic Med Invest. 6(1): 53-62.
  128-Article Text-445-2-10-20210706 (2).pdf Vol.6(1) Pages: 53-62
  
  
• E.K Umukoro, K.E Edje, E. Agbonifo-Chijiokwu, E.G Moke, E. Egbenede (2020) Use and effects of contraceptives among female secondary school students in Abraka Community, Delta State, Nigeria. , Journal of Applied Sciences and Environmental Management. 24(1): 153-156.
  Vol.24(1) Pages: 153-156.
  
  
• Obidike, N.A., Irikefe, O.S., Chukwuebuka, N.B., Kelechi, A.K., Basil,E.,& Ejime, A.-C (2020) Hypoglycemic and Hypolipidemic effects of potulaca oleracea Aqueous Extract is Mediated by Down Regulation of Cortisol. , Plant cell Biotechnology and Molecular Biology,21(41-42): 120-130
  Vol.21(41-42) Pages: 120-130
  
  
• A.E Ojieh, E.C Adegor, J.I Wilson, E.Agbonifo-Chijiokwu, E.G Moke (2020) Evaluating Effect of Prolonged Alcohol Consumption on Serum Gastrin and Secretin and Histo-architecture of the Stomach and Duodenum in Rats. , Tropical Journal of Health Sciences. 27(2):31-35
  Vol.27(2) Pages: 31-35
  
  
• Nwangwa, E.K, Anachuna, K.K, Chijiokwu-Agbonifo, E, and Odigie, O.M. (2018) Attenuation of Female Reproductive Hormones in Piroxicam Administered Wistar Rats., Int.J of forensic Med. Invest.
  Vol.4(1) Pages: 53-58
  
  
• Nwangwa, E. K., Anachuna, K. K. Ekhoye, E. I. and Chijiokwu-Agbonifo. E. (2018) Deteriorating Haemostatic functions of adult female Wistar rats mediated by activities of non-steroidal anti-inflammatory drugs (NSAIDS)-piroxicam and vitamin E. , Niger J. Physiol. Sci.
  Vol.33(1) Pages: 69-73
  
  
• A. O. Naiho, K. K. Anachuna, O. Omeru, B. C. Nwogueze, C. Ejime and M. O. Odigie (2018) Impacts of crude oil on reproductive indices of residents of oil producing area: a case study of Olomoro. , Annual Research and Review in Biology. 26(1): 1-7.
  DOI: 10.9734/ARRB/2018/39879 Vol. 26(1) Pages: 1-7
  
  
• E. Ojieh Anthony, C. Mordi Joseph, I. Ovaukpoaye S. and E. Agbonifo-Chijiokwu () Hypoglycemic and Hypolipidemic Indices of Ethanolic Leaf Extract of Nephrolepis Undulata in Alloxan Induced Diabetic Wistar Rats. , Biomedical & Pharmacology Journal
  Vol.13(3) Pages: 1-7
  
  
• Ojieh A.E, Wilson J.I, Nwogueze B.C, Agbonifo-Chijiokwu E., Ogagayere L.O () Predictability of type II Diabetes Mellitus from Salivary Surrogate Markers. , Int.J of forensic Med. Inves
  Vol.5(2) Pages: 1-8