Dr. IKPEFAN, EMMANUEL OLISE (ASSOCIATE PROFESSOR)

Email: ikpefanemmanuel@delsu.edu.ng

• Area of Specialization: Pharmacognosy (Anticancer evaluations of Nigerian Medicinal plants, phytochemistry, plant microscopy)
• Department of Pharmacognosy & Traditional Medicine


• Dr. Emmanuel Ikpefan is a lecturer/researcher of Pharmacognosy and Natural Products Chemistry at the Delta State University Abraka, Nigeria. He is a holder of a Bachelor of Science degree in Plant Biology and Biotechnology (Botany) as well as a Master’s and Doctorate degree in Pharmacognosy all from the prestigious University of Benin, Benin City Nigeria. His research focuses on the screening of Nigerian Medicinal Plants reputed for anticancer activities and isolating their bioactive constituents. He is a recipient of several travel grant such as the Royal Society of Chemistry (RSC) travel grant and the West African Research Center (WARC) as well as Gordon Research Seminar and Conference grants. He also obtained a Fellowship award of the Joint Non-align Movement for Science and Technology (NAM S&T) and International Center for Chemical and Biological Sciences (ICCBS), University of Karachi Pakistan. His research work apart from being published in revered journals, has recently resulted in the isolation of a novel anticancer compound (a diterpenoid) obtained from a Nigeria plant. He is an ambassador of the European Association of Cancer research, associate member, Royal Society of Chemistry (RSC) and a member of the Nigerian Society of Pharmacognosy (NSP) and Botanical Society of Nigeria (BOSON).

My Publications
1. Cletus Anes Ukwubile, Emmanuel Oise Ikpefan, Ademola Clement Famurewa (2023) Role of Chitosan-Loaded Solanine Glycoalkaloid from Solanum scabrum Mill. Leaf Extract as Anti-Inflammatory and In Vitro Anticancer Agents. , Turkish Journal of Pharmaceutical Sciences
   doi: 10.4274/tjps.galenos.2022.03837 Vol.20 Pages: 240-252
   
   
2. Cletus Anes Ukwubile , Emmanuel Oise Ikpefan , Musa Yusuf Dibal, Vivian Amarachukwu Umeano , David Nnamdi Menkiti , Clement Chidi Kaosi, Simon Paul, Ademola Clement Famurewa , Henry Nettey , Timothy Samuel Yerima (2023) Pharmacognostic profiles, evaluation of analgesic, anti-inflammatory and anticonvulsant activities of Newbouldia laevis (P. Beauv.) Seem. ex Bureau leaf and root extracts in Wistar rats. , Journal of Ethnopharmacology,
   10.1016/j.jep.2023.116632 Vol.314 Pages: 314 (2023) 116632
   
   
3. Cletus Anes Ukwubile , Troy Salvia Malgwi , Emmanuel Oise Ikpefan, Babagana Modu, Vivian Amarachukwu Umeano (2023) (2023) Evaluation of physicochemical parameters, acute and subchronic toxicities, and anti-diabetic activity of Spondias venulosa (Engl.) Mart. ex Engl. leaf extract on alloxan-induced diabetic rats. , Journal of Ethnopharmacology
   10.1016/j.jep.2023.116169 Vol.314 Pages: 116632
   
   
4. Ikpefan, EO, Ikpefan, JO, Ovbiagele,SO; Ejienyafu, U, Ojumah, CB (2023) (2023) Euphorbia Graminea Jacq. (Euphorbiaceae): A Comparative Antimicrobial Evaluations of Stem and Root Extracts. Journal of Applied Sciences & Environmental Management (JASEM). 27 (2), Journal of Applied Sciences & Environmental Management (JASEM)
   DOI:10.4314/jasem.v27i2.10 Vol.26 Pages: 249-255
   
   
5. Ikpefan, EO, Omosor, KK Ikpefan JO, Olowojoba, JI (2023) Evaluation of Potential Antimicrobial Activity of Stem Barks Extract of Persea americana (Mill) and its Solvent Fractions against Randomly Selected Pathogenic Bacteria and Fungi. , Journal of Applied Sciences & Environmental Management (JASEM).
   0.4314/jasem.v26i11.12 Vol.26 Pages: 1813-1820
   
   
6. Emmanuel O. Ikpefan, Collins O. Omekudo Felix O. Enwa (2022) Antimicrobial and antioxidant studies of the methanol leaves extract of Cnestis ferruginea Dc (connaraceae) , Journal of Current Biomedical Research,
   https://doi.org/10.54117/jcbr.v2i6.9 Vol.2(6). Pages: 683-699
   
   
7. Clement Oliseloke Anie, Emmanuel Oise Ikpefan , Felix Oghenemaro Enwa Lucy Umunade1, Ejiroghene Enomate (2022) (2022) Anti-methicillin resistant and growth inhibitory studies of extract and fractions of leaves of Bryophyllum pinnatum (Lam.) Kurz (Crassulaceae). , Herba Polonica
   10.2478/hepo-2022-0004 Vol.68 ( 1) Pages: 19-28
   
   
8. Ukwubile, C.A., Ikpefan, E.O., Malgwi, T.S., ...Milagawanda, H.H., Suleiman, A.U.(2021) (2021) Antioxidant, anti-inflammatory, analgesic and in vitro-in vivo cytotoxicity effects of Spondias Venulosa (Engl.) Engl. leaf extracts on MCF-7/S0.5 and OV7 cancer cell lines. , Scientific African
   https://doi.org/10.1016/j.sciaf.2021.e00917 Vol. 13, e00917 Pages: 1-11
   
   
9. EO.Ikpefan, B.A. Ayinde, E.O. Omeje , M. Azhar , Ahsana Dar Farooq , Z.A. Shah , F. Shaheenf , M.I. Choudhary (2021) Isolation and anti-cancer evaluation of two anti-proliferative constituents from the chloroform fraction of leaves of Conyza Sumatrensis (Retz.) E. H. Walker, Asteraceae., Scientific African
   https://doi.org/10.1016/j.sciaf.2021.e00854 Vol.13 e00854 Pages: 1-7
   
   
10. Ikpefan E.O, Ayinde B.O, Mudassar A and Farooq A.D (2021) In vitro antiproliferative and antioxidant assessment of the extract and partitioned fractions of leaves of Euphorbia graminea jacq. (Euphorbiaceae). , The Nigerian Journal of Pharmacy
    http://njpas.com.ng/wp-content/uploads/2020/12/12.NJPAS-20-B15-1.pdf Vol. 55 Pages: 26-31
    
    
11. Enwa Felix Oghenemaro, Ikpefen Emmanuel Oise, Damera Cynthia (2021) The Effects of Securinega virosa Leaves on Methicillin-Resistant Staphylococcus Aureus (MRSA)., International Journal of Pharmaceutical Research and Allied Sciences
    https://ijpras.com/article/the-effects-of-securinega-virosa-leaves-on-methicillin-resistant-staphylococcus-aureus-mrsa-ccndgbjouavoqdd Vol.10 Pages: 29-34
    
    
12. Ikpefan O. Emmanuel , Ayinde B. Adesina, Ikpefan J. Ohonmoimen, Mudassir Azah, Farooq A. Dar (2021) In vitro anticancer potential of Sacrocephalus latifolius leaves extract and its fractions on human MCF-7 and NCI-H460 cancer cell lines, Asian J Agric & Biol.
    DOI: 10.35495/ajab.2020.10.520 Vol.3 Pages: 1-7
    
    
13. Emmanuel O. Ikpefan, Bunniyamin A. Ayinde, Mudassir Ahzah (2021) Euphorbia graminea Jacq. (Euphorbiaceae): In-Vitro Cytotoxic, Phytotoxic and AntiProliferative Assessment of the Extract and Fractions of the Leaves , Tropical Journal of Natural Products Research
    https://www.tjnpr.org/viewarticle.aspx?articleid=1662 Vol.5 Pages: 1152-1157
    
    
14. Ukwubile CA,.Ikpefan EO, Malgwi TS, Bababe AB, .Odugu IA,.Angyu AN, Otalu O, .Bingari MS, Nettey HI (2020) Cytotoxic effects of new bioactive compounds isolated from a Nigerian anticancer plant Melastomastrum capitatum Fern. leaf extract, Scientific African
    https://doi.org/10.1016/j.sciaf.2020.e00421 Vol.8 Pages: 1-11
    
    
15. Ikpefan, E. O., Ikpefan, J.O., Ayinde, B. A., Mudassar, A. and Farooq, A. D.(2020). (2020) Securinega virosa leaf and root bark extracts: A comparative anti-cancer study against human breast (MCF-7) and lung (NCI-H460) cancer cell lines. , Nigerian Journal of Botany,33(1)
    http://boson.org.ng/Journal/Download?manuscriptId=MS000275 Vol. 33 Pages: 15-23
    
    
16. Ikpefan, E.O, Ukwubile C.A and Nwankwo L.U (2020) (2020) Cytotoxic, phytotoxic and insecticidal assessment of the crude extract and fractions of leaves of Conyza sumatrensis (Retz.) E. Walker Asteraceae. , Nigerian Journal of Pharmaceutical and Applied Science Research
    https://www.nijophasr.net/index.php/nijophasr/article/view/362 Vol.9 Pages: 52-58
    
    
17. Enwa, F.O., Ikpefan, E.O., Mokogwu, T.H.A. and Ubiebi, E.O (2020) The effect of aqueous and ethanol extracts of Pleurotus tuber regium as prebiotic and probiotic. , Nigerian Journal of Scientific Research
    Vol.19 Pages: 182-186
    
    
18. CA Ukwubile, EO Ikpefan, TS Malgwi, BO Umeokoli (2020) Pharmacognostic study and physiochemical assessment on the leaves of Melastomastrum capitatum Fern. anticancer plant in Nigeria , American Journal of Physiology, Biochemistry and Pharmacology
    https://www.ejmanager.com/mnstemps/61/61-1566066714.pdf?t=1628048576 Vol.10 Pages: 32-39
    
    
19. Enwa Felix Oghenemaro, Ikpefan Emmanuel Oise, Umukoro Oke (2020) In Vitro Antimicrobial evaluation of the methanol extract and Alkaloid Fraction of cotton plant (Gossypium Hirsutum) leaves against Methicillin Resistant Staphylococcus aureus , Trends in Science & Technology Journal
    http://ftstjournal.com/uploads/docs/53%20Article%205.pdf Vol.5 Pages: 669-672
    
    
20. Ikpefan, E.O (2019) Brine Shrimp Cytotoxic and Lemna minor Phytotoxic Evaluations of the Methanol Extracts of the Leaves, Stem and Root Barks of Sacrocephalus latifolius , Nigerian Journal of Basic and Applied Science
    https://www.ajol.info/index.php/njbas/article/view/196269 Vol.27 Pages: 136-141
    
    
21. Ikpefan EO, Ayinde B.A. Mudassar, Ahsana Dar Farooq (2019) (2019) Anticancer and antioxidant studies of the methanol extract and fractions of Conyza sumatrensis (Retz.) E. H. Walker (Asteraceae). , Nigerian Journal of Natural Products and Medicine
    https://www.ajol.info/index.php/njnpm/article/view/195764 Vol. 23 Pages: 77-82
    
    
22. EO Ikpefan (2019) Brine Shrimp Cytotoxic and Lemna minor Phytotoxic Evaluations of the Methanol Extracts of the Leaves, Stem and Root Barks of Sacrocephalus latifolius, Nigerian Journal of Basic and Applied Sciences (NJBAS)
    https://www.ajol.info/index.php/njbas/article/view/196269 Vol.27 Pages: 136-141
    
    
23. EO Ikpefan, BA Ayinde, A Mudassir, AD Farooq (2019) Comparative In Vitro Assessment of the Methanol Extracts of the Leaf, Stem, and Root Barks of Cnidoscolus aconitifolius on Lung and Breast Cancer Cell Lines. , Turkish Journal of Pharmaceutical Sciences
    http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.654.3989&rep=rep1&type=pdf Vol. 16 Pages: 375-379
    
    
24. Ikpefan E. Oise (2018) Comparative in vitro Dpph radical scavenging and growth inhibitory potentials of fractions of the methanol extract of the leaves of Securinega virosa. , International Journal of Biosciences
    http://dx.doi.org/10.12692/ijb/12.3.294-301 Vol. 12 Pages: 294-301
    
    
25. CA Ukwubile, EO Ikpefan, CT Samagoro, AY Abdulrahaman, A Nuhu (2018) Evaluation of Sperm and Haematological Parameters Boosting Potential of Breynia nivosa (W. Bull) Sm.(Euphorbiaceae) Leaf Extract in Male Albino Rats, Nigerian Journal of Pharmaceutical Research
    https://www.ajol.info/index.php/njpr/article/view/175441 Vol.14 Pages: 103-110
    
    
26. Ikpefan, E.O. (2018) Evaluation of the anti-proliferative and cytotoxic potentials of fractions of methanol leaf extract of Cnidoscolus aconitifolius. , Journal of Pharmaceutical and Allied Sciences
    https://www.ajol.info/index.php/jophas/article/view/168585 Vol. 15 Pages: 2684-2696
    
    
27. Emmanuel O. Ikpefan (2018) Preliminary Growth Inhibitory studies of the methanol extract and fractions of leaves of Artocarpus altilis. , Journal of Science and Practice of Pharmacy
    http://www.jsppharm.org/admin/12389900798187/2018_5_2_6-%20Ikpefan.pdf Vol.5 Pages: 275-280
    
    
28. Ukwubile CA, Troy SM, Ikpefan OE and Musa YD (2017) Preliminary Phytochemical Screening and In Vitro AnthelminthicActivity of Detarium Senegalense J.f Gmel (Fabaceae) Leaf Methanol Extract. , American Journal of Biotechnology and Bioinformatics
    https://escipub.com/Articles/AJOBB/AJOBB-2017-09-2802 Vol. 1 Pages: 1-6
    
    
29. Cletus .A. Ukwubile, Ikpefan E. Oise, Aguh .I. Bruno (2017) Application of Melastomastrum capitatum Fern. (Melastomataceae) Loaded-Exosome as Analgesic Drug Carrier in Acetic acid-Induced Swiss Albino Mice , International Biological and Biomedical Journal
    URL: http://ibbj.org/article-1-79-fa.html Vol. 3 Pages: 1-6
    
    
30. Cletus Anes Ukwubile, Ikpefan Emmanuel Oise and Shuaibu A. Umar (2017) Evaluation of In Vitro Anthelminthic Activity of Pseudocedrela kotschyi Harms. (Meliaceae) a Dry ZoneCeder Stem Bark Aqueous Extract. , International Biological and Biomedical Journal
    http://ibbj.org/article-1-86-fa.pdf Vol. 3 Pages: 30-33
    
    
31. Cletus A Ukwubile, Ikpefan E. Oise and Julius T. Nyiayem (2017) Preliminary Phytochemical Screening and Antibacterial Activity of Thaumatococcus daniellii (Benn.) Benth. (Marantaceae) Leaf Extract. , Journal of Bacteriology & Mycology
    DOI: 10.15406/jbmoa.2017.04.00086 Vol. 4 Pages: 2-5
    
    
32. Cletus .A. Ukwubile, Ikpefan .E. Oise, Aguh .I. Bruno, Agu Matthew O and Cynthia T. Samagoro (2016) Anti-Tumor and Anti-Ovarian Cancer Screening of Compound from the Leaf Methanol Extract of Annona Muricata Linn (Annonaceae). , International Journal of Research Studies in Biosciences,
    https://www.arcjournals.org/pdfs/ijrsb/v4-i11/7.pdf Vol. 4 Pages: 40-46
    
    
33. E Ikpefan, B Ayinde (2016) Preliminary Phytochemical and Cytotoxic Activity of The Aqueous and Chloroform Fractions of The Leaf of Persea Americana Mill (Lauraceae). , Nigerian Journal of Pharmaceutical and Applied Science Research
    https://www.nijophasr.net/index.php/nijophasr/article/view/107 Vol. 5 Pages: 15-20
    
    
34. CA Ukwubile, IE Oise (2016) Analgesic and anti-inflammatory activity of physalis angulata linn.(solanaceae) leaf methanolic extract in swiss albino mice, International Biological and Biomedical Journal
    http://ibbj.org/article-1-89-fa.pdf Vol.2 Pages: 167-170
    
    
35. Ikpefan E. O and Ayinde B.A (2015) Preliminary Phytochemical and Cytotoxic activity of the aqueous and chloroform fractions of the leaf of Persea americana. , Nigerian Journal of Pharmaceutical and Applied Science Research, 5(1)
    https://www.nijophasr.net/index.php/nijophasr/article/view/1 Vol. 5 Pages: 2684-2696
    
    
36. Ikpefan E.O., Ayinde B.A. and Ikpefan J.O. (2015) Comparative cytotoxic and spectrophotometric quantification of phytochemicals of the methanol extracts of the leaf and root bark of Securinega virosa (Roxb ex. Willd) Baill (Euphoriaceae) ., Journal of Pharmacy & Bioresources, 12 (2).
    https://www.ajol.info/index.php/jpb/article/view/126536 Vol.12 Pages: 106-111
    
    
37. Anaka, RI Ozolua, EO Ikpefan, DO Ogieva (2014) Phytochemical and Growth Inhibitory Studies on the leaf and root bark extracts of Securinega virosa (Roxb ex. Willd) baill (Euphoriaceae). , Journal of Pharmaceutical and Allied Sciences,
    https://www.ajol.info/index.php/jophas/article/view/131646 Vol.12 Pages: 2219-2227
    
    
38. ON Anaka, RI Ozolua, EO Ikpefan, DO Ogieva (2014) Anticonvulsant activity of the aqueous extract of Allium cepa L.(Amaryllidaceae) in rats and mice , Journal of Pharmacy & Bioresources
    https://www.ajol.info/index.php/jpb/article/view/107966 Vol.11 Pages: 1-7
    
    
39. ON Anaka, OJ Owolabi, E Ikpefan, O Okhiokpamwonyi (2013) Hypolipidemic activity of ethyl acetate fraction of methanolic seed extract of Persia Americana mill (Lauraceae) in rats , Journal of Pharmaceutical and Allied Sciences
    https://www.ajol.info/index.php/jophas/article/view/99835 Vol.10 Pages:  
    
    
40. EO Ikpefan, BA Ayinde, TD Gita (2013) In vitro comparative cytotoxic and growth inhibitory effects of the methanol extracts of the leaf stem and root barks of Cnidoscolus acontifolius (mill.) Johnst (euphorbiaceae), International Journal of Bioassays
    Vol. 2 Pages: 445-449
    
    
41. EO Ikpefan, BA Ayinde (2013) Comparative growth inhibitory assay of the methanol extract of the leaf and seed of Persea americana mill (Lauraceae) , Journal of Pharmacognosy and Phytochemistry
    Vol. 4 Pages:
    
    
42. Ikpefan E.O and Ayinde B.A (2013) Comparative growth inhibitory assay of the methanol extract of the Leaf and seed Of Persea americana Mill (Lauraceae). , Journal of Pharmacognosy and Phytochemistry
    https://www.phytojournal.com/archives?year=2013&vol=1&issue=6&ArticleId=74 Vol. 1 Pages: 101-107
    
    
43. Ikpefan EO, Fajana A and Olowojoba J.I (2013) Cytotoxic and Growth Inhibitory Effects of the Methanol Extract of Tridax Procumbens Linn (Asteraceae). , Journal of Pharmacognosy and Phytochemistry,
    https://www.phytojournal.com/archives?year=2013&vol=1&issue=6&ArticleId=74 Vol. 2 Pages: 101-107
    
    
44. Ikpefan Emmanuel Oise and Ayinde Buniyamin Adesina (2013) Preliminary phytochemical and comparative growth inhibitory assay of the aqueous and chloroform fractions of the methanol extract of the leaves of Persea americana Mill Lauraceae. , American Journal of Phytomedicine and Clinical Therapeutics
    Vol. 1 Pages: 594-604
    
    
45. BA Ayinde, EKI Omogbai, EO Ikpefan (2011) Comparative cytotoxic and antiproliferative effects of Persea americana mill (lauraceae) leaf, stem and root barks, Niger J Pharm Sci
    https://journals.abu.edu.ng/njps/viewabstract.php?paperid=87 Vol.10 Pages: 16-26
    
    
46. Ikpefan, E. O., Enwa F. O. and Emebrado, O. ( 2020) Euphorbia graminea Jacq. (Euphorbiaceae): The antimicrobial assessment of the extract and fractions of the leaves , Nig. J. Pure & Appl. Sci.
    http://njpas.com.ng/wp-content/uploads/2020/12/12.NJPAS-20-B15-1.pdf Vol.33 Pages: 182-186
    
    
47. Shabnam Javed, Ikpefan E. Oise, Lutfun Nahar, Fyaz M. D. Ismail ( 2016) Isolation, Identification and Antiproliferative Activity of Triterpenes from the Genus Monotheca A. DC, Records of Natural Products
    http://www.acgpubs.org/RNP/2016/Volume10/Issue%201... Vol.10 Pages: 782-787
    
    
48. IE Oise, AB Adesina, AA Oluwasegun ( 2014) Comparative phytochemical, cytotoxic and growth inhibitory effects of the leaf and root barks of Sarcocephalus Latifolius (JE Smith) EA Bruce (Rubiaceae) , Inter J Biosci
    http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.654.3989&rep=rep1&type=pdf Vol. 4 Pages: 162-9